EFFECT OF ASCORBIC ACID AGAINST LEAD (Pb) TOXICITY
نویسندگان
چکیده
Present study deals with effect of Vit. C against lead toxicity animals were divided into three groups of six rats each. One group of served as control which received only vehicle, second group was given lead acetate at a dose level of 0.3mg/ml for 7, 14 days chronically and third group received Vit. C (0.15mg/100ml) along with lead acetate and result were analyzed for hematological parameter i.e. RBC, WBC count and haemoglobin. It was noticed that hematological parameters were reduced due to lead acetate-treatment but when Vit. C was given along with lead the values tend to be normal at 14 days which suggest that Vit. C is a good antioxidant is overcome lead toxicity.
منابع مشابه
Evaluation of Lead Acetate Side Effects on Rat Hippocampus and the Effects of Vitamin C on These
Purpose: To investigate the effect of ascorbic acid against lead-induced neurotoxicity in the rat hippocampus. Materials and Methods: The heads of 40 male Sprague–Dawley rats were divided into 4 groups: normal, control, lead-treated and lead plus ascorbic acid-treated. Lead acetate (20mg/kg) was administered intraperitonealy to rats for 7days in third and fourth groups. During this period, rats...
متن کاملThe Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Apoptosis in Rat Offspring\'s Eye Retina
Introduction: Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. Methods: Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water...
متن کاملEffects of Nigella sativa oil and ascorbic acid against oxytetracycline-induced hepato-renal toxicity in rabbits
Objective(s): Oxytetracycline (OTC) is a broad spectrum antibiotic widely used for treatment of a wide range of infections. However, its improper human and animal use leads to toxic effects, including hepatonephrotoxicity. Our objective was to evaluate protective effects of Nigella sativa oil (NSO) and/or ascorbic acid (AA), against OTC-induced hepatonephrotoxicity in rabbits. Materials and Me...
متن کاملInfluences of water chemistry on the acute toxicity of lead to Pimephales promelas and Ceriodaphnia dubia.
The acute toxicity of lead (Pb) was examined for fathead minnows (Pimephales promelas; 96-h) and daphnids (Ceriodaphnia dubia; 48-h) in waters modified for hardness (as CaSO₄), dissolved organic carbon (DOC; as Aldrich humic acid) and alkalinity (as NaHCO₃) for parameterization of an acute freshwater biotic ligand model (BLM). Additionally, acute (96-h) and chronic (30-d) bioassays were perform...
متن کاملThe effect of ascorbic acid supplementation on the blood lead levels of smokers.
BACKGROUND The study subjects were 75 adult men (20 to 30 years of age), who smoked one pack of cigarettes per day (minimum) and had no clinical signs of ascorbic acid deficiency or lead toxicity. None had a history of industrial exposure to lead, and the blood-lead levels were anticipated to be below 1.45 micromol/L, the minimum blood level associated with toxicity symptoms. METHODS The men ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010